| Sekai Project | Norwalk, Los Angeles | 2007 |
| Sequential Circuits | São José | 1970 |
| Sheraton Hotels & Resorts | White Plains | 1937 |
| Sherwin-Williams | Cleveland | 1866 |
| Shimmer Women Athletes | Illinois, Chicago, Berwyn | 6 de novembro de 2005 |
| Shure | Niles | 1925 |
| Siebel Systems | Austin | 1993 |
| Sierra Nevada Corporation | Sparks | 1963 |
| Sigma-Aldrich | St. Louis | 1976 |
| Silicon Graphics | Sunnyvale, Mountain View | 9 de novembro de 1981 |
| Silver Pictures | Los Angeles | 1980 |
| Silvergate Capital | La Jolla | 1988 |
| Sinclair Broadcast Group | Hunt Valley, Cockeysville, Union Valley | 1971 |
| Singer Corporation | La Vergne, Estados Unidos, Singer Building | 1851 |
| Singularity University | Mountain View | 2010 |
| Skechers | Manhattan Beach | 1992 |
| Skybound Entertainment | Beverly Hills | 1992 |
| Skydance Media | Hollywood | 2006 |
| Skywalker Sound | Lucas Valley | 1975 |
| Smithfield Foods | Smithfield | 1936 |
| Snap Inc. | Santa Mônica, Venice | 16 de setembro de 2011 |
| Snap-on | Kenosha | 1920 |
| SolarCity | San Mateo, Califórnia | 2006 |
| Sony Corporation of America | Sony Building, Nova Iorque | 1960 |
| Sony Entertainment, Inc. | Nova Iorque | 2012 |
| Sony Music | Nova Iorque | 1 de janeiro de 2009 |
| Southern Company | Atlanta | 1945 |
| Southern Pacific Railroad | São Francisco | 1865 |
| Southwest Airlines | Dallas | 1967 |
| Soylent | Los Angeles | 2013 |
| SpaceX | Starbase | 14 de março de 2002 |
| SpaceXAI | Área da baía de São Francisco | 9 de março de 2023 |
| Spanx | Atlanta | 2000 |
| Specialized | Morgan Hill | 1974 |
| Spectravideo | — | 1981 |
| Springfield Armory | Geneseo | 1974 |
| Sprint Nextel | Overland Park | 1899 |
| Sprouts Farmers Market | Phoenix | julho 2002 |
| SRI International | Menlo Park | 1946 |
| Stage 6 Films | Culver City | 2007 |
| Standard Oil of Ohio | Cleveland | 1911 |
| Stanley Black & Decker | New Britain | 1843 |
| Starkey Hearing Technologies | Eden Prairie | 1967 |
| State Street Corporation | Boston | 1792 |
| Steelcase | Grand Rapids | 1912 |
| Stellantis North America | Chrysler Headquarters and Technology Center | 28 de abril de 2009 |
| Stepan Company | Northfield | 1932 |
| Stinson | Dayton | 1920 |