| Transmeta | Santa Clara | 1995 |
| Trek Bicycle Corporation | Waterloo | 1976 |
| Trimark Pictures | Santa Mônica | 1985 |
| Trump University | Nova Iorque | 2005 |
| Trumpet Records | — | 1951 |
| TRW Inc. | Euclid | 1901 |
| TUMI | Edison | 1975 |
| Turner Entertainment | Estados Unidos | 4 de agosto de 1986 |
| Turnitin | Oakland | 1997 |
| Turtle Beach Systems | Valhalla | 1975 |
| Twilio | São Francisco | 2008 |
| Two Steps From Hell | Los Angeles | 2006 |
| Ultimate Ears | Irvine | 1995 |
| Ultimate Pro Wrestling | Califórnia | 1998 |
| Underwood Typewriter Company | Nova Iorque | 1875 |
| Union Carbide | Danbury | 1957 |
| Union Iron Works | São Francisco | 1849 |
| United Fruit Company | Fort Lauderdale, Étoy | 30 de março de 1899 |
| United Parcel Service | Sandy Springs | 28 de agosto de 1907 |
| United Press International | Washington, D.C. | 1907 |
| United States Rubber Company | Naugatuck | 1892 |
| United Technologies Corporation | Hartford | 1929 |
| Unity Technologies | São Francisco | 2 de agosto de 2004 |
| Unocal Corporation | Los Angeles | 1890 |
| Uproxx | Culver City | 2008 |
| URS Corporation | Transamerica Pyramid, São Francisco | 1951 |
| Valero Energy | — | 1980 |
| Valid | Stamford | 1795 |
| Vanguard Animation | West Hollywood | 2002 |
| Varian Medical Systems | Palo Alto | 1948 |
| Venmo | Nova Iorque | 2009 |
| Viacom | One Astor Plaza | 31 de dezembro de 2005 |
| Viagogo | Londres | 2006 |
| Vic Firth | Boston | 1963 |
| Vice Media Group | Williamsburg | 1994 |
| Vicks | Cincinnati | 1890 |
| ViewSonic | Brea | 1987 |
| Vincent Bach Corporation | Mount Vernon | 1918 |
| Virgin Interactive | Irvine, Londres | 1983 |
| Visceral Games | Redwood City | 1998 |
| Vivendi Games | Los Angeles | 21 de fevereiro de 1996 |
| VMware | Palo Alto | 1998 |
| Vonage | Holmdel Township | 2001 |
| Vyond | San Mateo | 1 de novembro de 2007 |
| W. R. Grace and Company | Columbia | 1854 |
| Waldorf Astoria Hotels & Resorts | — | 2006 |
| Wall Street English | Baltimore | 1972 |
| Walt Disney Imagineering | Glendale | 1952 |