| Conn-Selmer | Elkhart | 1909 |
| Convergys | Cincinnati | 1998 |
| Cooper Tire & Rubber Company | Findlay | 1926 |
| Cord Automobile | Estados Unidos | 1929 |
| Costco | Issaquah | 1983 |
| CouchSurfing | São Francisco | 2 de abril de 2003 |
| CoverGirl | Maryland | 1961 |
| Coverity | São Francisco | novembro 2002 |
| Cox Communications | Phoenix | 1962 |
| Crackle | Culver City | julho 2007 |
| Credo Reference | Boston | 1999 |
| Cricket Wireless | San Diego | 1999 |
| CrossFit | Santa Cruz | 2000 |
| CrowdStrike | Austin | 29 de agosto de 2011 |
| Crunchbase | São Francisco | julho 2007 |
| Crystal Cruises | Los Angeles | 1988 |
| Culligan | Rosemont | 1936 |
| Cyan Worlds | Wilmington, Mead | 1987 |
| Cygnus Solutions | — | 13 de novembro de 1989 |
| Cypress Semiconductor | São José | 1982 |
| Cyrix | Richardson | 1988 |
| DallasNews Corporation | Dallas | 2008 |
| Danjaq LLC | Santa Mônica | 1962 |
| Datadog | Nova Iorque | 2010 |
| DC Universe | Burbank | 2018 |
| Dean Foods | Dallas | 1925 |
| Dean Guitars | Tampa | 1976 |
| Dell Technologies | Round Rock | 7 de setembro de 2016 |
| Delta Air Lines | Atlanta | 17 de junho de 1929 |
| Devon Energy | Oklahoma City | 1971 |
| Diamond Multimedia | Los Angeles | 1982 |
| Diamond-Star Motors | — | outubro 1985 |
| Dick's Sporting Goods | Coraopolis | 1948 |
| Dickies | Fort Worth | 1918 |
| DigitalOcean | Nova Iorque | agosto 2011 |
| Diller Scofidio + Renfro | — | 1981 |
| DiMarzio | Nova Iorque | 1975 |
| Discovery Communications | Nova Iorque | 1982 |
| Dish Network | Meridian | 1996 |
| Disney Interactive Media Group | Glendale | 1994 |
| Disney Streaming Services | Nova Iorque | 13 de agosto de 2015 |
| Disney Television Animation | Glendale | 5 de dezembro de 1984 |
| Doble steam car | Detroit, Waltham | 1909 |
| Docusign | São Francisco | 2003 |
| Dodge | Dodge Building | 14 de dezembro de 1900 |
| Dominion Energy | Richmond | 1983 |
| Doyle Dane Bernbach | Chicago, São Francisco, Londres | 1949 |
| Dr. Scholl's | Chicago, Londres | 1906 |